1-Octacosanol

1-Octacosanol is a very long-chain fatty alcohol that has diverse biological activities, including antibacterial, antifungal, anti-inflammatory, and antioxidative properties. It is active against the bacteria K. pneumoniae, S. flexneri, S. typhi, and E. faecalis (MICs = 4, 8, 2, and 32 µg/ml, respectively), as well as the pathogenic fungi T. ajelloi and T. rubrum (MICs = 4 and 32 µg/ml, respectively), but not the yeast C. albicans, C. lusitaniae, or C. krusei. It reduces the expression of TNF-alpha, inducible nitric oxide synthase (iNOS), IL-1beta, and IL-6 in RAW 264.7 cells stimulated with LPS when used at concentrations of 30 and 100 µg/ml. 1-Octacosanol (100 mg/kg per day) increases body weight, decreases diarrhea and hematochezia, and improves histopathological and morphological changes in the colon in a mouse model of ulcerative colitis induced by dextran sulfate sodium (DSS, Cay-23250). 1-Octacosanol (10, 50, or 100 mg/kg) reduces carbon tetrachloride-induced increases in serum transaminase, hepatic myeloperoxidase, and hepatic xanthine oxidase activity, as well as lipid peroxidation, in a rat model of acute liver injury progression. It also reverses decreases in hepatic superoxide dismutase and catalase activity, as well as glutathione (GSH) levels, in the same model.CAS Number: 557-61-9. Synonyms: Montanyl Alcohol, NSC 10770, NSC 57768. Molecular Formula: C28H58O. Formula Weight: 410.8. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. SMILES: OCCCCCCCCCCCCCCCCCCCCCCCCCCCC. InChi Code: InChI=1S/C28H58O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29/h29H,2-28H2,1H3. InChi Key: CNNRPFQICPFDPO-UHFFFAOYSA-N. Side Chain Carbon Sum: 28:0.