ZM 522

ZM 522 is an inhibitor of ecto-5'-nucleotidase, also known as CD73 (IC50s = 0.56 and 3.06 µM for the human and mouse enzymes, respectively), and a derivative of the triterpenoid betulinic acid (Cay-11686). It increases the levels of IFN-gamma secreted by isolated mouse spleen cells when used at a concentration of 10 µM in the presence of AMP.Formal Name: 3beta-[(4-fluorobenzoyl)oxy]-lup-20(29)-en-28-oic acid. CAS Number: 1454575-38-2. Molecular Formula: C37H51FO4. Formula Weight: 578.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 2 mg/ml, Ethanol: 2 mg/ml. lambdamax: 241 nm. SMILES: C[C@]1([C@]2([C@]([C@@]3([C@@](C(C)([C@H](CC3)OC(C4=CC=C(F)C=C4)=O)C)([H])CC2)C)([H])CC5)C)[C@@]5([H])[C@]([C@@H](CC6)C(C)=C)([H])[C@@]6(C(O)=O)CC1. InChi Code: InChI=1S/C37H51FO4/c1-22(2)25-14-19-37(32(40)41)21-20-35(6)26(30(25)37)12-13-28-34(5)17-16-29(33(3,4)27(34)15-18-36(28,35)7)42-31(39)23-8-10-24(38)11-9-23/h8-11,25-30H,1,12-21H2,2-7H3,(H,40,41)/t25-,26+,27-,28+,29-,30+,34-,35+,36+,37-/m0/s1. InChi Key: YVDDYENCDWEHSB-DWKDZXJCSA-N.