Zanamivir

Zanamivir is an inhibitor of influenza neuraminidase. It inhibits neuraminidase activity in clinical isolates of influenza A subtypes H1N1 and H3N2 and influenza B (geometric mean IC50s = 0.73, 1.64, and 11.21 nM, respectively). Zanamivir inhibits replication of influenza A and B in isolated human respiratory epithelial cells (EC90s = <0.01 mg/L and 0.25-0.54 mg/L, respectively). It reduces lung viral titers in mice infected with influenza A or B when administered intranasally at a dose of 0.4 mg/kg. Formulations containing zanamivir have been used in the prevention and treatment of influenza infection.Formal Name: 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid. CAS Number: 139110-80-8. Synonyms: GG 167, GR 121167X. Molecular Formula: C12H20N4O7. Formula Weight: 332.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.13 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 231 nm. SMILES: O=C(O)C1=C[C@H](NC(N)=N)[C@@H](NC(C)=O)[C@@]([C@H](O)[C@H](O)CO)([H])O1. InChi Code: InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1. InChi Key: ARAIBEBZBOPLMB-UFGQHTETSA-N.