Zaltoprofen

Zaltoprofen is a cyclooxygenase (COX) inhibitor that displays slight preferential inhibition for COX-2 (IC50s = 1.3 and 0.34 µM for COX-1 and COX-2, respectively). Independent of COX inhibition, zaltoprofen has also been reported to inhibit bradykinin-induced nociceptive responses by blocking the activation of protein kinase C.Formal Name: 10,11-dihydro-a-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid. CAS Number: 74711-43-6. Synonyms: CN 100, Soleton. Molecular Formula: C17H14O3S. Formula Weight: 298.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 16 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 11 mg/ml, PBS (pH 7.2): Insolulble. lambdamax: 228, 329 nm. SMILES: CC(C(O)=O)C1=CC(CC(C(C=CC=C2)=C2S3)=O)=C3C=C1. InChi Code: InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20). InChi Key: MUXFZBHBYYYLTH-UHFFFAOYSA-N.