Z-L-Phe-CMK

Z-L-Phe-CMK is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (Mpro), also known as 3C-like protease (3CLpro, Ki = 306 nM). It is selective for SARS-CoV Mpro over calpain, trypsin, and thrombin (Kis = 10, >100, and >100 µM, respectively). Z-L-Phe-CMK (20 µM) also inhibits the protein-protein interaction between p53 and MDM2 in U2OS osteosarcoma cells. It has been used as a building block in the synthesis of HIV protease inhibitors.Formal Name: N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid, phenylmethyl ester. CAS Number: 26049-94-5. Synonyms: NSC 251810, SL 01, Z-L-Phe Chloromethyl Ketone, ZPCK. Molecular Formula: C18H18ClNO3. Formula Weight: 331.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 33 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 2 mg/ml. lambdamax: 259 nm. SMILES: O=C(CCl)[C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2. InChi Code: InChI=1S/C18H18ClNO3/c19-12-17(21)16(11-14-7-3-1-4-8-14)20-18(22)23-13-15-9-5-2-6-10-15/h1-10,16H,11-13H2,(H,20,22)/t16-/m0/s1. InChi Key: OYHLRJGDELITAF-INIZCTEOSA-N.