Yamogenin

Yamogenin is a steroidal sapogenin that has been found in fenugreek (T. foenum graecum) and has diverse biological activities. It inhibits activation of the liver X receptor (LXR) induced by the LXRalpha and LXRbeta agonist T0901317 (Cay-71810) in HepG2 cells in a reporter assay when used at concentrations of 5 or 10 µM. Yamogenin (10 µM) decreases triglyceride levels in primary mouse hepatocytes. It is cytotoxic to HaCaT keratinocytes, as well as HeLa cervical and SKOV3 ovarian cancer cells (IC50s = 16.4, 19.6, and 23.9 µg/ml, respectively).Formal Name: (3beta,25S)-spirost-5-en-3-ol. CAS Number: 512-06-1. Synonyms: Neodiosgenin, NSC 226132. Molecular Formula: C27H42O3. Formula Weight: 414.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: 10 mg/ml, DMF: insol, DMSO: insol, Ethanol: 1 mg/ml, PBS (pH 7.2): insol. SMILES: C[C@@H]1[C@]2(OC[C@@H](C)CC2)O[C@]3([H])[C@@]1([H])[C@@]4([C@@]([C@@]5([H])[C@]([C@@]6(C(C[C@H](CC6)O)=CC5)C)([H])CC4)([H])C3)C. InChi Code: InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17-,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1. InChi Key: WQLVFSAGQJTQCK-CAKNJAFZSA-N. Origin: Plant/Dioscorea collettii.