(+)-WIN 55,212-2 (mesylate)

(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve. This effect is fully counteracted by rimonabant (Cay-9000484) at a concentration of 10 nM, by decreasing Ca2+ concentrations below 0.2 mM, or by the IP3 receptor antagonist xestospongin C (Cay-64950) at a concentration of 1 µM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 value of 26 µM.Formal Name: [(3R)-2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone, monomethanesulfonate. CAS Number: 131543-23-2. Molecular Formula: C27H26N2O3 . CH3SO3H. Formula Weight: 522.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 219, 246, 330 nm. SMILES: O=C(C1=CC=CC2=C1C=CC=C2)C3=C(C)N(C4=C3C=CC=C4OC5)[C@@H]5CN6CCOCC6.CS(=O)(O)=O. InChi Code: InChI=1S/C27H26N2O3.CH4O3S/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28,1-5(2,3)4/h2-11,20H,12-17H2,1H3,1H3,(H,2,3,4)/t20-,/m1./s1. InChi Key: FSGCSTPOPBJYSX-VEIFNGETSA-N.