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Sphingosine-1-phosphate (S1P) modulates skin, vascular endothelial, and immune cells via five distinct G protein-coupled receptors. The S1P type 1 receptor, S1P1, also known as EDG-1, mediates endothelial, lymphoid, and neuronal cell responses to S1P, as well as the synthetic agonist FTY720. W123 is an analog of FTY720 that is a competitive antagonist of S1P1, as measured by GTPgammaS activation, mitogen-activated protein kinase recruitment, cell migration, and ligand-induced receptor internalization. It has a Ki value of 0.69 µM when assessed by SEW2871-induced activation of S1P1. Its specificity for other S1P receptor subtypes remains to be determined.Formal Name: 3-(2-(3-hexylphenylamino)-2-oxoethylamino)propanoic acid. CAS Number: 1345982-24-2. Molecular Formula: C17H26N2O3. Formula Weight: 306.4. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.3 mg/ml. lambdamax: 244 nm. SMILES: OC(CCNCC(NC1=CC(CCCCCC)=CC=C1)=O)=O. InChi Code: InChI=1S/C17H26N2O3/c1-2-3-4-5-7-14-8-6-9-15(12-14)19-16(20)13-18-11-10-17(21)22/h6,8-9,12,18H,2-5,7,10-11,13H2,1H3,(H,19,20)(H,21,22). InChi Key: JXZQHAWCGSVWRW-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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