Vincristine-d3

Vincristine-d3 is intended for use as an internal standard for the quantification of vincristine (Cay-11764) by GC- or LC-MS. Vincristine is a vinca alkaloid that has been found in C. rosea and has anticancer activities. It inhibits tubulin polymerization in a cell-free assay (Ki = 0.085 µM) and induces mitotic arrest in U937 cells when used at a concentration of 10 nM. In vivo, vincristine (3 mg/kg) reduces tumor growth in rhabdomyosarcoma patient-derived xenograft (PDX) mouse models. Formulations containing vincristine have been used in the treatment of various cancers.Formal Name: 22-oxo-vincaleukoblastine-d3. CAS Number: 1246817-09-3. Synonyms: Kyocristine-d3, Leurocristine-d3, Lilly 37231-d3, Novopharm-d3, VCR-d3. Molecular Formula: C46H53D3N4O10. Formula Weight: 828.0. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble, DMSO: soluble, Methanol: soluble. SMILES: CC[C@]1([C@H]2OC(C([2H])([2H])[2H])=O)[C@@]3([H])[C@](C(C4=C5)=CC([C@](C6=C7C8=CC=CC=C8N6)(C[C@](C[C@@]9(O)CC)([H])C[N@@](C9)CC7)C(OC)=O)=C5OC)(CCN3CC=C1)[C@](N4C=O)([H])[C@@]2(O)C(OC)=O. InChi Code: InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1/i3D3. InChi Key: OGWKCGZFUXNPDA-GBBJZFCTSA-N. Origin: Synthetic.