Vigabatrin

Vigabatrin is an irreversible GABA transaminase (GABA-T) inhibitor. It inhibits rat brain GABA-T when used at a concentration of 0.1 mM. Vigabatrin is selective for rat brain GABA-T over P. fluorescens GABA-T at 10 mM and is 100-fold selective over rat brain glutamic acid decarboxylase (GAD). Vigabatrin (1,500 mg/kg) decreases brain GABA-T activity without affecting GAD activity in mice. It reduces the incidence of myoclonus in a mouse model of audiogenic seizures. Vigabatrin also increases the electroconvulsive threshold in mouse model of maximal electroshock-induced seizures and reduces the number of clonic convulsions induced by pentylenetetrazol (PTZ, Cay-18682) in mice. Formulations containing vigabatrin have been used in the treatment of seizures and infantile spasms.Formal Name: 4-amino-5-hexenoic acid. CAS Number: 68506-86-5. Synonyms: gamma-Vinyl GABA. Molecular Formula: C6H11NO2. Formula Weight: 129.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: C=CC(CCC(O)=O)N. InChi Code: InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9). InChi Key: PJDFLNIOAUIZSL-UHFFFAOYSA-N.