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Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM). It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions. VE-821 also sensitizes cancer cells to chemotherapy.Formal Name: 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide. CAS Number: 1232410-49-9. Synonyms: ATR Inhibitor IV. Molecular Formula: C18H16N4O3S. Formula Weight: 368.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 20 mg/ml. lambdamax: 224, 304, 382 nm. SMILES: O=C(C1=NC(C2=CC=C(S(C)(=O)=O)C=C2)=CN=C1N)NC3=CC=CC=C3. InChi Code: InChI=1S/C18H16N4O3S/c1-26(24,25)14-9-7-12(8-10-14)15-11-20-17(19)16(22-15)18(23)21-13-5-3-2-4-6-13/h2-11H,1H3,(H2,19,20)(H,21,23). InChi Key: DUIHHZKTCSNTGM-UHFFFAOYSA-N.
Keywords:
ATR Inhibitor IV, 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
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