Tubercidin

Tubercidin is a nucleoside analog that has been found in S. tubercidicus and has diverse biological activities. It is active against S. faecalis (IC50 = 0.02 µM) and cytotoxic to P388 murine leukemia and A549 human lung adenocarcinoma cells (IC50s = 0.008 and 0.019 µg/ml, respectively). Tubercidin reduces infection of Calu-3 cells by severe acute respiratory coronavirus 2 (SARS-CoV-2, EC50 = 0.05 µM) but is toxic to A549 cells expressing human ACE2 (A549-ACE2) and Vero cells. Tubercidin (5 mg/kg per day), in combination with the nucleoside transport inhibitor prodrug NBMPR-P, increases survival in a mouse model of schistosomiasis but is hepato- and nephrotoxic and induces mortality when administered alone at the same dose for four days.Formal Name: 7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS Number: 69-33-0. Synonyms: 7-Deazaadenosine, 7-DZA, NSC 56408. Molecular Formula: C11H14N4O4. Formula Weight: 266.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly soluble, DMSO: 2 mg/ml, PBS (pH 7.2): 0.25 mg/ml. SMILES: O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC(N)=C3C=C2. InChi Code: InChI=1S/C11H14N4O4/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(18)7(17)6(3-16)19-11/h1-2,4,6-8,11,16-18H,3H2,(H2,12,13,14)/t6-,7-,8-,11-/m1/s1. InChi Key: HDZZVAMISRMYHH-KCGFPETGSA-N. Origin: Synthetic.