Trofosfamide

Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Cay-13849) that has antiproliferative activities. It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80, and 160 mg/kg. Trofosfamide (100 mg/kg) inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction. It reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats when administered at a dose of 40 mg/kg.Formal Name: N,N,3-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, 2-oxide. CAS Number: 22089-22-1. Synonyms: NSC 109723. Molecular Formula: C9H18Cl3N2O2P. Formula Weight: 323.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/mL, DMSO: 30 mg/mL, Ethanol: 50 mg/mL, PBS (pH 7.2): 10 mg/mL. SMILES: ClCCN(CCCl)P1(OCCCN1CCCl)=O. InChi Code: InChI=1S/C9H18Cl3N2O2P/c10-2-6-13-5-1-9-16-17(13,15)14(7-3-11)8-4-12/h1-9H2. InChi Key: UMKFEPPTGMDVMI-UHFFFAOYSA-N.