(-)-Triptonide

(-)-Triptonide is a diterpenoid that has been found in T. wilfordii and has diverse biological activities, including immunosuppressant and anticancer properties. It inhibits IL-2 production and DNA synthesis in phytohemagglutinin-stimulated T cells (EC50s = 2.46 and 3.2 ng/ml, respectively). (-)-Triptonide inhibits the proliferation of PC3, DU145, and LNCaP cells (IC50s = 11.96, 10.26, 12.01 nM, respectively). It induces cell cycle arrest at the G2/M phase and increases apoptosis in PC3 cells in a concentration-dependent manner. (-)-Triptonide (10 mg/kg per day) reduces tumor growth in a PC3 mouse xenograft model.Formal Name: (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione. CAS Number: 38647-11-9. Synonyms: NSC 165677, Triptonide. Molecular Formula: C20H22O6. Formula Weight: 358.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: Partially soluble. lambdamax: 215 nm. SMILES: O=C1OCC2=C1CC[C@@]3(C)[C@@]2([H])C[C@@]4([H])[C@]5(O4)[C@@]3(O6)[C@]6([H])[C@@](O7)([H])[C@@]7(C(C)C)C5=O. InChi Code: InChI=1S/C20H22O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14H,4-7H2,1-3H3/t11-,12-,13-,14-,17-,18-,19+,20+/m0/s1. InChi Key: SWOVVKGLGOOUKI-ZHGGVEMFSA-N. Origin: Plant/Tripterygium wilfordii Hook F.