(-)-Triptonide is a diterpenoid that has been found in T. wilfordii and has diverse biological activities, including immunosuppressant and anticancer properties. It inhibits IL-2 production and DNA synthesis in phytohemagglutinin-stimulated T cells (EC50s = 2.46 and 3.2 ng/ml, respectively). (-)-Triptonide inhibits...

Description: 1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1/2 and p38 MAPK inhibitors. Target:...