Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Trimipramine-d3 (maleate) is intended for use as an internal standard for the quantification of... more
Product information "Trimipramine-d3 (maleate)"
Trimipramine-d3 (maleate) is intended for use as an internal standard for the quantification of trimipramine (maleate) (Cay-15921) by GC- or LC-MS. Trimipramine is a tricyclic antidepressant. It selectively binds the serotonin (5-HT) transporter (SERT) over the norepinephrine transporter (NET) and dopamine transporter (DAT, Kds = 149, 2,450, and 3,780 nM, respectively) and acts as a histamine H1 receptor antagonist (Ki = 0.02 µM) that is selective for histamine H1 over H2, H3, and H4 receptors (Kis = 0.04, >100, and 43.6 µM, respectively). Trimipramine binds to muscarinic acetylcholine and alpha1- and alpha2-adrenergic receptors (Kds = 58, 24, and 580 nM, respectively), as well as dopamine D1 and D2 receptors and 5-HT receptor subtypes 5-HT1C and 5-HT2 (Kis = 346.7, 57.5, 537, and 19.5 nM, respectively). It reduces immobility time in the forced swim test in rats when administered at a dose of 10 mg/kg. Formulations containing trimipramine have previously been used in the treatment of depression.Formal Name: 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,2-dimethyl-N-(methyl-d3)propan-1-amine, (2Z)-2-butenedioate. Molecular Formula: C20H23D3N2 . C4H4O4. Formula Weight: 413.5. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: CN(C([2H])([2H])[2H])CC(C)CN1C2=C(C=CC=C2)CCC3=C1C=CC=C3.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C20H26N2.C4H4O4/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22,5-3(6)1-2-4(7)8/h4-11,16H,12-15H2,1-3H3,1-2H,(H,5,6)(H,7,8)/b,2-1-/i2D3,. InChi Key: YDGHCKHAXOUQOS-QWPULOJDSA-N.
Keywords: | 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,2-dimethyl-N-(methyl-d3)propan-1-amine, (2Z)-2-butenedioate |
Supplier: | Cayman Chemical |
Supplier-Nr: | 31919 |
Properties
Application: | GC-MS, LC-MS, Internal standard, Quantification, Noradrenalin & serotonin transporter inhibitor |
MW: | 413.5 D |
Formula: | C20H23D3N2 . C4H4O4 |
Purity: | >99% deuterated forms (d1-d3) |
Format: | Solid |
Database Information
KEGG ID : | K05035 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H315, H319, H335, H361 |
P Phrases: | P201, P202, P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P308+313, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed