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Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.Formal Name: N,3,4,5-tetrahydroxy-benzenecarboximidamide, monohydrochloride. CAS Number: 95933-75-8. Synonyms: CF 233 (hydrochloride). Molecular Formula: C7H8N2O4 . HCl. Formula Weight: 220.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 2 mg/ml, Ethanol: 0.25 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 220, 280 nm. SMILES: Cl.ONC(=N)c1cc(O)c(O)c(O)c1. InChi Code: InChI=1S/C7H8N2O4.ClH/c8-7(9-13)3-1-4(10)6(12)5(11)2-3,/h1-2,10-13H,(H2,8,9),1H. InChi Key: KBKNXSNOQYLIRI-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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