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Product information "trans-trismethoxy Resveratrol-d4"
trans-trismethoxy Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-trismethoxy resveratrol (Cay-10188) by GC- or LC-MS. trans-trismethoxy Resveratrol is a polyketide synthase-derived stilbene originally isolated from Virola cuspidata that has diverse biological activities. It is cytotoxic to several cancer cell lines, including PC3, KB, HT-29, SW480, and HL-60 cells (IC50s =3.6, 10.2, 16.1, 54, and 2.5 µM, respectively). trans-trismethoxy Resveratrol (15 µM) inhibits TNF-alpha-induced activation of NF-kappaB in HEK293T cells in a reporter assay. It inhibits angiogenesis in zebrafish embryos when used at a concentration of 0.1 µM.Formal Name: 3-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-6-methoxy-benzene-1,2,4,5-d4. CAS Number: 1089051-64-8. Synonyms: (E)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzene diol-d4, TMS-d4, trans-3,5,4'-Trimethoxystilbene-d4. Molecular Formula: C17H14D4O3. Formula Weight: 274.4. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 218, 305, 320 nm. SMILES: COc1ccc(cc1)\C=C/c1cc(OC)cc(OC)c1. InChi Code: InChI=1S/C17H18O3/c1-18-15-8-6-13(7-9-15)4-5-14-10-16(19-2)12-17(11-14)20-3/h4-12H,1-3H3/b5-4+/i6D,7D,8D,9D. InChi Key: GDHNBPHYVRHYCC-XEGZCKIBSA-N. Origin: Plant/Virola cuspidata.
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