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trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol (Cay-70675) by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 µM, respectively), but not COX-2 (EC50s = >100 µM and 85 µM, respectively). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014, EC50 = 27 µM). trans-Resveratrol (1-25 µmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 µM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCalpha, aromatase/CYP19, and DNA polymerases alpha and delta (IC50s = 37, 50, 20, in vitro and/or ex vivo. It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.Formal Name: 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol-2,3,5,6-d4. CAS Number: 1089051-56-8. Synonyms: (E)-Resveratrol-d4. Molecular Formula: C14H8D4O3. Formula Weight: 232.3. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: >100 mg/ml, DMSO: >50mg/ml, Ethanol: >50mg/ml, PBS (pH 7.2): <100 µg/ml. lambdamax: 307, 320 nm. SMILES: Oc1ccc(cc1)\C=C/c1cc(O)cc(O)c1. InChi Code: InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+/i3D,4D,5D,6D. InChi Key: LUKBXSAWLPMMSZ-RRQWMZAJSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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