TPT-260 (hydrochloride)

Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer's disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.Formal Name: carbamimidothioic acid, C,C'-[2,5-thiophenediylbis(methylene)] ester, dihydrochloride. CAS Number: 2076-91-7. Synonyms: NSC 55712, R55. Molecular Formula: C8H12N4S3 . 2HCl. Formula Weight: 333.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 247, 326 nm. SMILES: N=C(N)SCC1=CC=C(CSC(N)=N)S1.Cl.Cl. InChi Code: InChI=1S/C8H12N4S3.2ClH/c9-7(10)13-3-5-1-2-6(15-5)4-14-8(11)12,,/h1-2H,3-4H2,(H3,9,10)(H3,11,12),2*1H. InChi Key: DSODRWWHAUGSGD-UHFFFAOYSA-N.