Topiramate

Topiramate is a sugar sulfamate with anticonvulsant activity. It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 µM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro. It also increases GABAA receptor-mediated chloride ion flux. Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.). Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.Formal Name: 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose, 1-sulfamate. CAS Number: 97240-79-4. Synonyms: McN 4853, RWJ 17021, TPM. Molecular Formula: C12H21NO8S. Formula Weight: 339.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 15 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 0.15 mg/ml. SMILES: CC1(C)O[C@H]2[C@H]3[C@H](OC(C)(C)O3)CO[C@@]2(COS(N)(=O)=O)O1. InChi Code: InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1. InChi Key: KJADKKWYZYXHBB-XBWDGYHZSA-N.