Tiotropium-d3 (bromide)

Tiotropium-d3 is intended for use as an internal standard for the quantification of tiotropium (Cay-15773) by GC- or LC-MS. Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors). It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled aerosol) confers complete protection against acetylcholine-induced bronchospasms in anesthetized dogs. Formulations containing tiotropium have been used in the treatment of chronic obstructive pulmonary disease (COPD).Formal Name: (1alpha,2beta,4beta,5alpha,7beta)-7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9-methyl-9-(methyl-d3)-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide. CAS Number: 1127226-56-5. Molecular Formula: C19H19D3NO4S2 . Br. Formula Weight: 475.4. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Methanol: Slightly Soluble. SMILES: O=C(C(C1=CC=CS1)(O)C2=CC=CS2)O[C@H]3C[C@H]4[C@H]5[C@H](O5)[C@H]([N+]4(C([2H])([2H])[2H])C)C3.[Br-]. InChi Code: InChI=1S/C19H22NO4S2.BrH/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15,/h3-8,11-13,16-17,22H,9-10H2,1-2H3,1H/q+1,/p-1/t11-,12-,13+,16-,17+,/i1D3,/t11-,12-,13+,16-,17+,20?,. InChi Key: DQHNAVOVODVIMG-YQZQVDIVSA-M.