Thiamethoxam

Thiamethoxam is a neonicotinoid insecticide and a prodrug form of the neonicotinoid insecticide clothianidin (Cay-29605). It binds to nicotinic acetylcholine receptors (nAChRs) with low affinity (IC50 = 5,000 nM for housefly head membranes) and does not activate non-desensitizing nAChRs in cockroach neurons in vitro (IC50 = >3,000 nM). Thiamethoxam induces mortality in a variety of insects, including A. craccivora, M. persicae, and S. littoralis when administered in contact/feeding assays (LC80s = 12, 3, and 3 mg AI/L, respectively) and via systemic administration (LC80s = 0.8, 0.2, and 0.8 mg AI/L, respectively), as well as N. lugens and D. balteata in contact/feeding assays (LC80s = 0.8 mg AI/L for both). Thiamethoxam also induces 100% mortality of second instar larvae of the fall armyworm S. frugiperda and the tobacco budworm H. virescens in leaf-dip bioassays when used at a concentration of 200 mg/L. Formulations containing thiamethoxam have been used in the control of insects in agriculture.Formal Name: 3-[(2-chloro-5-thiazolyl)methyl]tetrahydro-5-methyl-N-nitro-4H-1,3,5-oxadiazin-4-imine. CAS Number: 153719-23-4. Molecular Formula: C8H10ClN5O3S. Formula Weight: 291.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: CN1COCN(CC2=CN=C(Cl)S2)/C1=N/[N+]([O-])=O. InChi Code: InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3/b11-8+. InChi Key: NWWZPOKUUAIXIW-DHZHZOJOSA-N.