Tetrahydroepiberberine

Tetrahydroepiberberine is an alkaloid originally isolated from P. rhoeas that has diverse biological activities. It is active against the fungus C. albicans (MIC = 8 µg/ml), as well as the bacteria E. coli, P. aeruginosa, P. mirabilis, K. pneumoniae, A. baumannii, S. aureus, and B. subtilis (MICs = 32-64 µg/ml, respectively). Tetrahydroepiberberine (16 µg/ml) inhibits the cytopathogenic effect of parainfluenza-3 (PI-3) virus in Vero cells. It decreases the viability of HaCaT keratinocytes (IC50 = 150 µM).Formal Name: 6,6a,11,14-tetrahydro-8,9-dimethoxy-12H-benzo[a]-1,3-benzodioxolo[4,5-g]quinolizine. CAS Number: 38853-67-7. Synonyms: Sinactine. Molecular Formula: C20H21NO4. Formula Weight: 339.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble. SMILES: COC1=C(C=C2C(C3N(CC2)CC4=C5OCOC5=CC=C4C3)=C1)OC. InChi Code: InChI=1S/C20H21NO4/c1-22-18-8-13-5-6-21-10-15-12(3-4-17-20(15)25-11-24-17)7-16(21)14(13)9-19(18)23-2/h3-4,8-9,16H,5-7,10-11H2,1-2H3. InChi Key: UWEHVAXMSWXKRW-UHFFFAOYSA-N. Origin: Plant/Sinomenium acutum.