Tetrahydrocoptisine

Tetrahydrocoptisine is an alkaloid that has been found in C. impatiens and has anti-inflammatory and antioxidant activities. It inhibits LPS-induced NF-kappaB activation and production of nitric oxide (NO), TNF-alpha, and IL-6 in isolated mouse peritoneal macrophages when used at concentrations ranging from 0.001 to 1 µg/ml. Tetrahydrocoptisine (10 and 30 mg/kg) inhibits xylene-induced ear edema in mice, and it decreases serum levels of TNF-alpha in a mouse model of LPS-induced septic shock. It reduces the severity of ethanol-induced gastric ulcers in mice when administered at doses of 10 or 20 mg/kg.Formal Name: 6,7,12b,13-tetrahydro-4H-bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizine. CAS Number: 4312-32-7. Synonyms: NSC 110382, NSC 404529, (R,S±)-Stylopine. Molecular Formula: C19H17NO4. Formula Weight: 323.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: 5 mg/ml, DMF: 1 mg/ml. SMILES: C12=CC=C3C(CN4CCC5=CC6=C(C=C5C4C3)OCO6)=C1OCO2. InChi Code: InChI=1S/C19H17NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,6-7,15H,3-5,8-10H2. InChi Key: UXYJCYXWJGAKQY-UHFFFAOYSA-N. Origin: Plant/Unidentified sp..