Tenuifolin

Tenuifolin is a saponin that has been found in P. tenuifolia and has neuroprotective activity. It inhibits beta-secretase (BACE) activity by 54.4% when used at a concentration of 10 µg/ml. Tenuifolin (2 µg/ml) inhibits secretion of amyloid-beta (1-40) (Abeta40) and Abeta42 from COS-7 cells expressing wild-type amyloid precursor protein isoform 695 (APP695 WT) or Swedish mutant APP695 (APP695 Swe). It prevents decreases in PC12 cell viability induced by Abeta (25-35) when used at concentrations of 20 and 40 µg/L. Tenuifolin (3 and 9 mg/kg) inhibits increases in the escape latency and total swimming distance induced by Abeta (25-35) in the Morris water maze in mice.Formal Name: (4alpha)-3beta-(beta-D-glucopyranosyloxy)-2beta,27-dihydroxy-olean-12-ene-23,28-dioic acid. CAS Number: 20183-47-5. Synonyms: Presenegenin 3-O-glucoside. Molecular Formula: C36H56O12. Formula Weight: 680.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: CC1(C)CC[C@@]2(C(O)=O)[C@@](C3=CC[C@@]([C@](C[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@]5(C)C(O)=O)(C)[C@@]5([H])CC6)([H])[C@]6(C)[C@]3(CO)CC2)([H])C1. InChi Code: InChI=1S/C36H56O12/c1-31(2)10-11-35(30(45)46)12-13-36(17-38)18(19(35)14-31)6-7-22-32(3)15-20(39)27(34(5,29(43)44)23(32)8-9-33(22,36)4)48-28-26(42)25(41)24(40)21(16-37)47-28/h6,19-28,37-42H,7-17H2,1-5H3,(H,43,44)(H,45,46)/t19-,20-,21+,22+,23+,24+,25-,26+,27-,28-,32+,33+,34-,35-,36-/m0/s1. InChi Key: DBJLNNAUDGIUAE-YGIRLYIESA-N. Origin: Plant/Polygalae radix.