Tenovin-3

Tenovin-3 is a small molecule activator of p53 transcriptional activity. It increases p53 activity in MCF-7 cells when used at a concentration of 10 µM. It also increases the level of K40-acetylated alpha-tubulin in H1299 cells and inhibits SIRT2 protein deacetylase activity.Formal Name: N-[[(4-aminophenyl)amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide. CAS Number: 1011301-27-1. Molecular Formula: C18H21N3OS. Formula Weight: 327.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml, DMSO: 0.25 mg/ml. lambdamax: 203, 253, 277 nm. SMILES: CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(N)C=C2)=S)=O)C=C1. InChi Code: InChI=1S/C18H21N3OS/c1-18(2,3)13-6-4-12(5-7-13)16(22)21-17(23)20-15-10-8-14(19)9-11-15/h4-11H,19H2,1-3H3,(H2,20,21,22,23). InChi Key: NLAXTZPUTNGRDU-UHFFFAOYSA-N.