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Product information "Tenofovir Disoproxil (fumarate)"
Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir (Cay-13874). Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase. Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.Formal Name: (5-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-2,4,6,8-tetraoxa-5-phosphanonanedioic acid, 1,9-bis(1-methylethyl) ester 5-oxide, (2E)-2-butenedioate. CAS Number: 202138-50-9. Synonyms: Bis(POC)-PMPA. Molecular Formula: C19H30N5O10P . C4H4O4. Formula Weight: 635.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 14 mg/ml, Ethanol: 5 mg/ml. lambdamax: 209, 260 nm. SMILES: O=P(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)CO[C@H](C)CN1C=NC2=C(N)N=CN=C21.O=C(O)/C=C/C(O)=O. InChi Code: InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24,5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22),1-2H,(H,5,6)(H,7,8)/b,2-1+/t14-,/m1./s1. InChi Key: VCMJCVGFSROFHV-WZGZYPNHSA-N.
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