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TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1, IC50 = 1.5 µM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 µM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 µM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.Formal Name: N,N'-(sulfonyldi-4,1-phenylene)bis[2-chloro]-acetamide. CAS Number: 17328-16-4. Synonyms: NSC 30176. Molecular Formula: C16H14Cl2N2O4S. Formula Weight: 401.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml. lambdamax: 257, 283 nm. SMILES: ClCC(NC1=CC=C(S(C2=CC=C(NC(CCl)=O)C=C2)(=O)=O)C=C1)=O. InChi Code: InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22). InChi Key: SHRCVZJKZJGIHQ-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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