T-2 Toxin-13C24

T-2 toxin-13C24 is intended for use as an internal standard for the quantification of T-2 toxin (Cay-11444) by GC- or LC-MS. T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1beta, TNF-alpha, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.Formal Name: (2S,2'R,3'R,4'S,5'S,5a'R,7'S,9a'R)-4'-(acetoxy-13C2)-5a'-((acetoxy-13C2)methyl-13C)-3'-hydroxy-5',8'-di(methyl-13C)-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-7'-yl-2,2',3,3',4',5',5a',6',7',8',9',9a'-13C12 3-(methyl-13C)butanoate-1,2,3,4-13C4. Synonyms: Fusariotoxin T-2-13C24, Insariotoxin-13C24, Mycotoxin T-2-13C24. Molecular Formula: [13C]24H34O9. Formula Weight: 490.3. Purity: >98%. Formulation: (Request formulation change), A 25 µg/ml solution in acetonitrile. Solubility: Acetonitrile: soluble. SMILES: [13CH3][13C]1=[13CH][13C@]2([H])[13C@]([13C@]([13C@H](O[13C]([13CH3])=O)[13C@H]3O)([13CH3])[13C@]4([13CH2]O4)[13C@]3([H])O2)([13CH2]O[13C]([13CH3])=O)[13CH2][13C@@H]1O[13C]([13CH2][13CH]([13CH3])[13CH3])=O. InChi Code: InChI=1S/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3/t16-,17+,19+,20+,21+,22+,23+,24-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1,10+1,11+1,12+1,13+1,14+1,15+1,16+1,17+1,18+1,19+1,20+1,21+1,22+1,23+1,24+1. InChi Key: BXFOFFBJRFZBQZ-SOROUPBBSA-N.