STO-609

STO-609 is a calcium/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor (IC50s = 120 and 40 ng/ml for CaMKKalpha and CaMKKbeta, respectively). It is selective for CaMKKs over CaMKI, CaMKII, CaMKIV, MLCK, PKC, PKA, and p42 MAPK (IC50s = >10,000 ng/ml for all). STO-609 inhibits phosphorylation of CaMKI and AMP-activated protein kinase (AMPK) in chicken sperm in the presence of extracellular calcium, as well as reduces chicken sperm motility, in a concentration-dependent manner. It decreases hypothalamic neuropeptide Y (Npy) and agouti-related protein (Agrp) expression and cumulative food intake in mice when administered intracerebroventricularly as a 20 µM solution at a continuous rate of 0.5 µL/hour . STO-609 (3 µg/animal, i.c.v.) increases cortical, striatal, and total infarct volume in a mouse model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO).Formal Name: 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid. CAS Number: 52029-86-4. Molecular Formula: C19H10N2O3. Formula Weight: 314.3. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A solid. Solubility: 100 mM NaOH: 10 mg/ml, DMSO: 1 mg/ml. lambdamax: 221, 287, 297, 390 nm. SMILES: O=C(C(C=CC(C1=NC2=C(N13)C=CC=C2)=C45)=C4C=CC=C5C3=O)O.O=C(C6=CC=C7)N8C9=C(C=CC=C9)N=C8C%10=C6C7=CC(C(O)=O)=C%10. InChi Code: InChI=1S/2C19H10N2O3/c22-18-12-5-3-4-10-8-11(19(23)24)9-13(16(10)12)17-20-14-6-1-2-7-15(14)21(17)18,22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h2*1-9H,(H,23,24). InChi Key: RNMGNCQBZCDYFU-UHFFFAOYSA-N.