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15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH) is a key enzyme involved in the inactivation of PGs and related eiscosanoids. It functions by catalyzing the oxidation of primary PGs to their 15-keto metabolites. Two types of 15-hydroxy PGDH have been identified: type-I is NAD+-dependent primarily using eicosanoids as substrates, while type-II uses either NAD+ or NADP+ as cofactors and bears broader substrate specificity. STK393606 is a competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH with an IC50 value of 26.4 nM and a Ki value of 5 nM. It demonstrates selectivity for 15-hydroxy PGDH when profiled across a panel of related dehydrogenase or reductase enzymes.Formal Name: 2-[[(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)thio]methyl]-benzonitrile. CAS Number: 355827-05-3. Molecular Formula: C14H9BrN4S. Formula Weight: 345.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 12 mg/ml. lambdamax: 311 nm. SMILES: BrC1=CNC2=NC(SCC3=CC=CC=C3C#N)=NC2=C1. InChi Code: InChI=1S/C14H9BrN4S/c15-11-5-12-13(17-7-11)19-14(18-12)20-8-10-4-2-1-3-9(10)6-16/h1-5,7H,8H2,(H,17,18,19). InChi Key: DEYMHFHACXKPOV-UHFFFAOYSA-N.
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