STF-62247

STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 µM).Formal Name: N-(3-methylphenyl)-4-(4-pyridinyl)-2-thiazolamine. CAS Number: 315702-99-9. Molecular Formula: C15H13N3S. Formula Weight: 267.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2)(1:5): 0.2 mg/ml. lambdamax: 246, 296 nm. SMILES: Cc1cccc(c1)Nc1scc(n1)c1ccncc1. InChi Code: InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18). InChi Key: KATNUHQNJGNLPW-UHFFFAOYSA-N.