STF-31

Glucose transporter 1 (Glut1) is an inducible carrier of pentoses and hexoses, including glucose. STF-31 is an inhibitor of Glut1 (IC50 = ~1 µM) that blocks glucose uptake. It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress Glut1. Although STF-31 binds Glut1, suggesting a direct effect, STF-31 also inhibits nicotinamide phosphoribosyltransferase, an enzyme that induces Glut1 expression. STF-31 is also toxic to human pluripotent stem cells (hPSCs) and can be used to selectively eliminate hPSCs from mixed cultures.Formal Name: 4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-benzamide. CAS Number: 724741-75-7. Molecular Formula: C23H25N3O3S. Formula Weight: 423.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.2 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 231, 264 nm. SMILES: O=C(C1=CC=C(CNS(=O)(C2=CC=C(C(C)(C)C)C=C2)=O)C=C1)NC3=CN=CC=C3. InChi Code: InChI=1S/C23H25N3O3S/c1-23(2,3)19-10-12-21(13-11-19)30(28,29)25-15-17-6-8-18(9-7-17)22(27)26-20-5-4-14-24-16-20/h4-14,16,25H,15H2,1-3H3,(H,26,27). InChi Key: NGQPRVWTFNBUHA-UHFFFAOYSA-N.