SQ 22,536

SQ 22,536 is an inhibitor of adenylyl cyclase with an IC50 value of 13 µM for inhibition of prostaglandin E1-stimulated increase in cAMP in intact platelets. It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research paradigms, inhibiting cAMP elevation at concentrations of 100-300 µM without effecting relaxation.Formal Name: 9-(tetrahydro-2-furanyl)-9H-purin-6-amine. CAS Number: 17318-31-9. Synonyms: NSC 53339. Molecular Formula: C9H11N5O. Formula Weight: 205.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 209, 260 nm. SMILES: NC1=C2C(N(C3OCCC3)C=N2)=NC=N1. InChi Code: InChI=1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12). InChi Key: UKHMZCMKHPHFOT-UHFFFAOYSA-N.