Solifenacin (succinate)

Solifenacin is a competitive antagonist of M1, M2, and M3 muscarinic acetylcholine receptors (Kis = 25, 125, and 10 nM, respectively, for the human receptors). It inhibits calcium mobilization induced by carbachol (carbamoylcholine, Cay-14486) in isolated guinea pig detrusor muscle cells (Ki = 4 nM). Solifenacin inhibits carbachol-induced contraction of isolated guinea pig urinary bladder smooth muscle. In vivo, solifenacin (0.03-1 mg/kg) inhibits carbachol-induced increases in urinary bladder pressure in anesthetized rats. Formulations containing solifenacin have been used in the treatment of overactive bladder.Formal Name: butanedioic acid, compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate. CAS Number: 242478-38-2. Synonyms: YM-67905. Molecular Formula: C23H26N2O2 . C4H6O4. Formula Weight: 480.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(O[C@H]1CN2CCC1CC2)N3[C@@H](C4=CC=CC=C4)C5=CC=CC=C5CC3.OC(CCC(O)=O)=O. InChi Code: InChI=1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19,5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2,1-2H2,(H,5,6)(H,7,8)/t21-,22-,/m0./s1. InChi Key: RXZMMZZRUPYENV-VROPFNGYSA-N.