SC-57461A

Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Cay-20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM). It blocks both the hydrolase and aminopeptidase activity in vitro. SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 (Cay-20210) or 6-keto prostaglandin F1alpha production (Cay-15210). Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.Formal Name: N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-beta-alanine, monohydrochloride. CAS Number: 423169-68-0. Molecular Formula: C20H25NO3 . HCl. Formula Weight: 363.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 3 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 266, 277 nm. SMILES: CN(CCC(O)=O)CCCOC(C=C1)=CC=C1CC2=CC=CC=C2.Cl. InChi Code: InChI=1S/C20H25NO3.ClH/c1-21(14-12-20(22)23)13-5-15-24-19-10-8-18(9-11-19)16-17-6-3-2-4-7-17,/h2-4,6-11H,5,12-16H2,1H3,(H,22,23),1H. InChi Key: SBBJJLDNKNNWFJ-UHFFFAOYSA-N.