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SC-514 is a selective and reversible inhibitor of IkappaB kinase 2 (IKK2) (IC50 = 3-12 µM) that displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. In synovial fibroblasts stimulated with interleukin (IL)-1beta, SC-514 attenuates NF-kappaB-mediated expression of IL-6, IL-8, and cyclooxygenase-2 (IC50s = 20, 20, and 8 µM, respectively). SC-514 also reduces NF-kappaB-mediated expression of other genes, including iNOS in LPS-stimulated smooth muscle cells and TLR2 in TNF-activated astrocytes.Formal Name: 4-amino-[2,3'-bithiophene]-5-carboxamide. CAS Number: 354812-17-2. Synonyms: GK 01140. Molecular Formula: C9H8N2OS2. Formula Weight: 224.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml. SMILES: NC(=O)c1sc(cc1N)c1cscc1. InChi Code: InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12). InChi Key: BMUACLADCKCNKZ-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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