This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
The enzyme Delta6 desaturase mediates the conversion of linoleic acid to gamma-linolenic acid (GLA), which can then be elongated to dihomo-gamma-linolenic acid (DGLA). DGLA can then be used as a substrate for Delta5 desaturase to produce arachidonic acid (AA), the fatty acid that is used to generate eicosanoids. SC-26196 is an inhibitor of Delta6 desaturase (IC50 = 0.2 µM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to arachidonic acid (AA). It is selective for Delta6 desaturase, as IC50 values for Delta5 and Delta9 desaturases exceed 200 µM and it has no effect on the conversion of dihomo-gamma-linolenic acid to AA. SC-26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice. It also blocks aging-related increases in AA in myocardial cardiolipin in mice, attenuating contractile dysfunction without impacting mitochondrial oxidative stress.Formal Name: alpha,alpha-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile. CAS Number: 218136-59-5. Synonyms: alpha,alpha-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile. Molecular Formula: C27H29N5. Formula Weight: 423.6. Purity: >98%. Solubility: DMF: 12 mg/mL, DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL, DMSO: 5 mg/mL. lambdamax: 303 nm. SMILES: N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCN(/N=C/C4=CN=CC=C4)CC3. InChi Code: InChI=1S/C27H29N5/c28-23-27(25-10-3-1-4-11-25,26-12-5-2-6-13-26)14-8-16-31-17-19-32(20-18-31)30-22-24-9-7-15-29-21-24/h1-7,9-13,15,21-22H,8,14,16-20H2/b30-22+. InChi Key: QFYKXKMYVYOUNJ-JBASAIQMSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
More information