Sauchinone

Sauchinone is a lignan that has been found in S. chinensis and has diverse biological activities. It inhibits LPS-induced expression of the genes encoding inducible nitric oxide synthase (iNOS), TNF-alpha, and COX-2 (IC50s = =10 µM for all), as well as LPS-induced activation of NF-kappaB and nuclear translocation of NF-kappaB p65 in RAW 264.7 cells. Sauchinone reduces hydrogen peroxide-induced increases in heat shock protein 70 (Hsp70) levels and cell death in C2C12 mouse skeletal muscle myoblasts. In vivo, sauchinone (10 and 30 mg/kg) reduces hepatic formation of thiobarbituric acid reactive substances (TBARS), plasma levels of alanine aminotransferase (ALT), and hepatocyte cell death in a mouse model of iron overload-induced liver injury. Sauchinone (10 mg/kg) reduces infarct size and heart levels of phosphorylated p38 MAPK and JNK in a rat model of myocardial ischemia-reperfusion injury.Formal Name: (5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one. CAS Number: 177931-17-8. Molecular Formula: C20H20O6. Formula Weight: 356.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/mL, DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL, DMSO: 2 mg/mL. lambdamax: 238, 299 nm. SMILES: O=C1[C@]2([H])C[C@@H](C)[C@H](C)[C@]3([H])[C@@]2([H])[C@@]4(OC5=C3C=C6C(OCO6)=C5)C(OCO4)=C1. InChi Code: InChI=1S/C20H20O6/c1-9-3-11-13(21)5-17-20(25-8-24-17)19(11)18(10(9)2)12-4-15-16(23-7-22-15)6-14(12)26-20/h4-6,9-11,18-19H,3,7-8H2,1-2H3/t9-,10+,11+,18+,19+,20+/m1/s1. InChi Key: GMTJIWUFFXGFHH-WPAOEJHSSA-N. Origin: Plant/Saururaceae.