Salidroside

Salidroside is a glycoside that has been found in R. rosea and has diverse biological activities, including antioxidant, anti-apoptotic, neuroprotective, and anti-inflammatory properties. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) and ABTS (Cay-27317) radicals with EC50 values of 81.54 and 30.94 µg/ml, respectively, in cell-free assays. Salidroside (50 and 100 µM) inhibits apoptosis and production of reactive oxygen species (ROS) induced by amyloid-beta (25-35) (Abeta (23-35)) in SH-SY5Y neuroblastoma cells. It decreases infarct volume by 17.9% in a rat model of focal cerebral ischemia-reperfusion injury induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 12 mg/kg. Salidroside (20, 50, and 100 mg/kg, p.o.) increases survival and reduces plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), TNF-alpha, and malondialdehyde (MDA) levels in a mouse model of liver injury induced by acetaminophen (Cay-10024).Formal Name: 2-(4-hydroxyphenyl)ethyl-beta-D-glucopyranoside. CAS Number: 10338-51-9. Synonyms: Rhodioloside. Molecular Formula: C14H20O7. Formula Weight: 300.3. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC1=CC=C(C=C1)CCO[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2. InChi Code: InChI=1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1. InChi Key: ILRCGYURZSFMEG-RKQHYHRCSA-N.