S49076 HCl
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Solid. Soluble in DMSO. S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can... more
Product information "S49076 HCl"
Solid. Soluble in DMSO. S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can potently block cellular phosphorylation of MET, AXL and FGFRs and inhibit downstream signalling in vitro and in vivo. S49076 can inhibit the proliferation of MET- and FGFR2-dependent gastric cancer cells, block MET-driven migration of lung carcinoma cells, and inhibit colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. S49076 has also been shown to cause tumour growth arrest in bevacizumab-resistant tumours in xenograft models.
| Keywords: | S-49076 . HCl, (Z)-3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione hydrochloride |
| Supplier: | SYNkinase |
| Supplier-Nr: | 1217 |
Properties
| Application: | MET AXL/MER & FGFR1/2/3 inhibitor |
| MW: | 475,0 D |
| Formula: | C22H23ClN4O4S |
| Purity: | >95% |
| Format: | Solid |
Database Information
| CAS : | 1265965-19-2| Matching products |
| KEGG ID : | K05099 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +20°C (International: +20°C) |
| GHS Hazard Pictograms: |
|
| H Phrases: | H302, H317, H332 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed