S32826

Autotaxin is a lysophospholipase D, cleaving lysophosphatidylcholine to produce choline and lysophosphatidic acid (LPA). S32826 is a potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin beta with an IC50 of 8.8 nM. It shows similar effectiveness against the three known autotaxin isoforms (alpha, beta, and gamma). It has no effect on a variety of receptors and enzymes, with the exceptions of src (IC50 = 6 µM) and phosphatase 1B (IC50 = 15 µM). S32826 inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 µM.Formal Name: P-[[4-[(1-oxotetradecyl)amino]phenyl]methyl]-phosphonic acid. CAS Number: 1096770-84-1. Molecular Formula: C21H36NO4P. Formula Weight: 397.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 2 mg/ml. lambdamax: 250 nm. SMILES: O=C(CCCCCCCCCCCCC)NC1=CC=C(CP(O)(O)=O)C=C1. InChi Code: InChI=1S/C21H36NO4P/c1-2-3-4-5-6-7-8-9-10-11-12-13-21(23)22-20-16-14-19(15-17-20)18-27(24,25)26/h14-17H,2-13,18H2,1H3,(H,22,23)(H2,24,25,26). InChi Key: OUXAHVRWFHOKHY-UHFFFAOYSA-N.