(S)-Mephenytoin

(S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin 4-hydroxylase. CYP2C19 metabolizes a variety of therapeutic agents, including omeprazole, proguanil, diazepam, propranolol, citalopram, imipramine, and certain barbiturates. Genetic defects in CYP2C19 result in poor metabolism of these compounds, and (S)-mephenytoin can be used to screen for such mutations by assaying its metabolites in urine. (S)-Mephenytoin has anticonvulsant activities.Formal Name: (5S)-5-ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione. CAS Number: 70989-04-7. Synonyms: (+)-Mephenytoin, (S)-5-ethyl-3-methyl-5-Phenylhydantoin. Molecular Formula: C12H14N2O2. Formula Weight: 218.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 15 mg/ml. SMILES: O=C1[C@@](C2=CC=CC=C2)(CC)NC(N1C)=O. InChi Code: InChI=1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16)/t12-/m0/s1. InChi Key: GMHKMTDVRCWUDX-LBPRGKRZSA-N.