Rubiadin-1 methyl ether

Rubiadin-1 methyl ether is an anthraquinone that has been found in Heterophyllaea pustulata and has diverse biological activities. It generates superoxide radicals in isolated human neutrophils and monocytes when used at a concentration of 20 µg/ml, an effect that can be enhanced by UV radiation. Rubiadin-1 methyl ether (0.1, 1, and 10 µM) inhibits M-CSF- and RANKL-induced differentiation of osteoclasts. It inhibits C. tropicalis biofilm formation (MIC = 31.3 µg/ml for a clinical isolate). Rubiadin-1 methyl ether (30 mg/kg) reduces LPS-induced increases in bronchoalveolar fluid (BALF) levels of TNF-alpha, IL-6, and IFN-gamma in a mouse model of acute lung injury.Formal Name: 3-hydroxy-1-methoxy-2-methyl-9,10-anthracenedione. CAS Number: 7460-43-7. Synonyms: NSC 59063, RBM. Molecular Formula: C16H12O4. Formula Weight: 268.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 239, 281 nm. SMILES: O=C1C2=C(C(C3=C(C(C)=C(C=C13)O)OC)=O)C=CC=C2. InChi Code: InChI=1S/C16H12O4/c1-8-12(17)7-11-13(16(8)20-2)15(19)10-6-4-3-5-9(10)14(11)18/h3-7,17H,1-2H3. InChi Key: NTBUBTCXACOEEC-UHFFFAOYSA-N. Origin: Plant/Paederia scandens.