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Rubiadin-1 methyl ether is an anthraquinone that has been found in Heterophyllaea pustulata and has diverse biological activities. It generates superoxide radicals in isolated human neutrophils and monocytes when used at a concentration of 20 µg/ml, an effect that can be enhanced by UV radiation. Rubiadin-1 methyl ether (0.1, 1, and 10 µM) inhibits M-CSF- and RANKL-induced differentiation of osteoclasts. It inhibits C. tropicalis biofilm formation (MIC = 31.3 µg/ml for a clinical isolate). Rubiadin-1 methyl ether (30 mg/kg) reduces LPS-induced increases in bronchoalveolar fluid (BALF) levels of TNF-alpha, IL-6, and IFN-gamma in a mouse model of acute lung injury.Formal Name: 3-hydroxy-1-methoxy-2-methyl-9,10-anthracenedione. CAS Number: 7460-43-7. Synonyms: NSC 59063, RBM. Molecular Formula: C16H12O4. Formula Weight: 268.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 239, 281 nm. SMILES: O=C1C2=C(C(C3=C(C(C)=C(C=C13)O)OC)=O)C=CC=C2. InChi Code: InChI=1S/C16H12O4/c1-8-12(17)7-11-13(16(8)20-2)15(19)10-6-4-3-5-9(10)14(11)18/h3-7,17H,1-2H3. InChi Key: NTBUBTCXACOEEC-UHFFFAOYSA-N. Origin: Plant/Paederia scandens.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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