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RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor (Kd = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively). In vivo, topical administration of RU-58841 (1-100 µg per animal) reduces size of the flank organ without affecting sex organs in a dose-dependent manner in hamsters. It has no effect on sex organ weight in intact rats when administered percutaneously, subcutaneously, or orally at doses up to 1 mg per animal. RU-58841 (5% v/v) also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness.Formal Name: 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)-benzonitrile. CAS Number: 154992-24-2. Molecular Formula: C17H18F3N3O3. Formula Weight: 369.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 25 mg/ml, Ethanol: 33 mg/ml, Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml. lambdamax: 262 nm. SMILES: O=C1N(C2=CC(C(F)(F)F)=C(C#N)C=C2)C(C(C)(C)N1CCCCO)=O. InChi Code: InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3. InChi Key: ARBYGDBJECGMGA-UHFFFAOYSA-N.
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