Rp-Cyclic AMPS (triethylammonium salt)

Rp-Cyclic AMPS (Rp-cAMPS) is a non-hydrolyzable phosphorothioate analog of cAMP. It is a competitive inhibitor of cAMP-dependent protein kinases I and II (IC50s = 12.5 and 4.5 µM, respectively). Rp-cAMPS is not hydrolyzed by bovine heart cAMP phosphodiesterase but can be hydrolyzed by yeast phosphodiesterase. It is broadly used in research involving cAMP-dependent signaling in vitro and in vivo.Formal Name: cyclic 3',5'-[hydrogen (R)-phosphorothioate] adenosine, triethylammonium salt. CAS Number: 151837-09-1. Synonyms: Rp-cAMPS. Molecular Formula: C10H11N5O5PS . C6H16N. Formula Weight: 446.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 260 nm. SMILES: O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H]4[C@H]1O[P@@](OC4)([S-])=O.CC[NH+](CC)CC. InChi Code: InChI=1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7,1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13),4-6H2,1-3H3/t4-,6-,7-,10-,21-,/m1./s1. InChi Key: OXIPZMKSNMRTIV-RNSTXJOVSA-N.