Ro 67-7476

Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 µM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 µM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM).Formal Name: 2S-(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine. CAS Number: 298690-60-5. Molecular Formula: C17H18FNO2S. Formula Weight: 319.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 30 mg/ml. lambdamax: 231 nm. SMILES: FC(C=C1)=CC=C1[C@@H]2CCCN2S(C3=CC=C(C)C=C3)(=O)=O. InChi Code: InChI=1S/C17H18FNO2S/c1-13-4-10-16(11-5-13)22(20,21)19-12-2-3-17(19)14-6-8-15(18)9-7-14/h4-11,17H,2-3,12H2,1H3/t17-/m0/s1. InChi Key: DAEHFYNGSSBGSS-KRWDZBQOSA-N.