Riluzole (hydrochloride)

Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 µM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals at an ED50 value of 4 mg/kg. Formulations containing riluzole have been explored as therapeutics for slowing disease progression of amyotrophic lateral sclerosis.Formal Name: 6-(trifluoromethoxy)-2-benzothiazolamine, monohydrochloride. CAS Number: 850608-87-6. Synonyms: PK 26124. Molecular Formula: C8H5F3N2OS . HCl. Formula Weight: 270.7. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, Ethanol: 30 mg/mL, Ethanol:PBS (pH7.2)(1:20): 0.04 mg/mL, Water: Soluble. SMILES: NC1=NC2=C(S1)C=C(OC(F)(F)F)C=C2.Cl. InChi Code: InChI=1S/C8H5F3N2OS.ClH/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5,/h1-3H,(H2,12,13),1H. InChi Key: QEAOELIJQRYJJS-UHFFFAOYSA-N.