Rilpivirine-d6 (hydrochloride)

Rilpivirine-d6 is intended for use as an internal standard for the quantification of rilpivirine (Cay-21559) by GC- or LC-MS. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC50 value of 0.51 nM. It is active against NNRTI-resistant HIV strains with EC50 values of less than 1 nM for L100I, K103N, V106A, G190A, and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates (EC50s = In vivo, rilpivirine, when used in combination with cabotegravir, lamivudine (Cay-18514), and abcavir, reduces the plasma viral titer in HIV-1 infected humanized mice.Formal Name: 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-di(methyl-d3)phenyl]amino]-2-pyrimidinyl]amino]-benzonitrile, monohydrochloride. Molecular Formula: C22H12D6N6 . HCl. Formula Weight: 408.9. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: [2H]C([2H])([2H])C(C=C(/C=C/C#N)C=C1C([2H])([2H])[2H])=C1NC2=NC(NC3=CC=C(C#N)C=C3)=NC=C2.Cl. InChi Code: InChI=1S/C22H18N6.ClH/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19,/h3-9,11-13H,1-2H3,(H2,25,26,27,28),1H/b4-3+,/i1D3,2D3,. InChi Key: KZVVGZKAVZUACK-QHNUCIEHSA-N.